The One Health Cycle explains how the management of a zoonotic pandemic with a One Health approach works. A zoonotic pathogen from wild animals moves into livestock, pets, fur animals, or directly to humans. The One Health approach introduces the processes of “early education” (green) and “early prediction” (blue) that boost the early detection (red) and control (orange) efforts. Early education increases the number of young people able to recognize a zoonosis, while the Artificial Intelligence systems used in early prediction increase the ability to predict an outbreak in wildlife before the spillover can occur. Anthropogenic pressure, deforestation and bushmeat, climate changes, illegal animal trade, and intensive animal farm are all human-generated causal factors causing the emergence and resurgence of zoonotic diseases (Image credit Paolo Zucca).